Professor of Biophysical Chemistry
Intrinsically disordered proteins in norm and pathology
Protein misfolding and amyloid formation in neurodegenerative diseases
Liquid-liquid phase separation and membraneless organelles in biology
My lab is interested in understanding the biophysical and biochemical properties of† intrinsically disordered proteins (IDPs), which constitute more than half of the eukaryotic proteome. A subset of IDPs also undergo aggregation towards insoluble, fibrillar amyloid structures while some undergo liquid-liquid phase separation (LLPS) to form biomolecular condensates as membraneless organelles in cells.† Our lab is interested in understanding the fundamental physical, chemical and biological principles that underlie these processes in both norm and pathology.
We are specifically focused on the amyloidogenic proteins, amyloid-b (Ab), a-synuclein (aS). Tau and TDP-43 that play a role in a variety of different neurodegenerative diseases such as Alzheimer disease (AD), Parkinsonís disease (PD), Frontotemporal dementia (FTD), Amyotrophic lateral sclerosis (ALS) etc. We are also interested in cystine-rich proteins called granulins (GRNs) both as model IDPs as well as modulators of amyloids and LLPS in neurodegenerative diseases.
We collaborate with several research groups, whose valuable contributions keep our quest alive...
†††††††††† Vladimir Uversky: University of South Florida, FL
†††††††††† Preetam Ghosh:† Virginia Commonwealth University, VA
†††††††††† Ashwin Vaidya:† Montclair State University, NJ.
†††††††††† Melissa Moss:† University of South Carolina, SC
†††††††††† Yona Levites:† University of Florida, FL
†††††††††† Sarah Morgan: University of Southern Mississippi.
†††††††††† Ayyalusamy Ramamoorthy: University of Michigan
†††††††††† Ulrich Hansmann: University of Oklahoma
Graduate Students:† You will be trained in Protein Biophysical Chemistry, Spectroscopy and Molecular Biology and Rational Design and Molecular Recognition tools.† Contact me for further details.
118 College Drive, # 5043
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